Synonym for annoyance is "bother"

affliction [noun]

means "curse"
cancer, annoyance, bane, calamity, evil, misfortune

aggravation [noun]

means "irritation"
exasperation, annoyance, grief, pique, bother, provocation

bane [noun]

means "affliction"
cancer, annoyance, curse, calamity, evil, misfortune

curse [noun]

means "affliction"
cancer, annoyance, bane, calamity, evil, misfortune

discomposure [noun]

means "disturbance"
agitation, confusion, discomfiture, annoyance, embarrassment, uneasiness

drag [noun]

means "bother"
annoyance

ennui [noun]

means "weariness"
annoyance, fatigue, tiredness, boredom

exasperation [noun]

means "irritation"
aggravation, annoyance, grief, pique, bother, provocation

fret [noun]

means "agitation"
annoyance, harassment, irritation, vexation, worry

harassment [noun]

means "nuisance"
bother, plague, aggravation, pest, annoyance

huff [noun]

means "offence"
anger, annoyance, pique, rage, fit

irritability [noun]

means "petulance"
testiness, anger, peevishness, exasperation, vexation, annoyance

irritant [noun]

means "nuisance"
pest, bother, annoyance, burden, aggravation, inconvenience

irritation [noun]

means "mild anger"
exasperation, vexation, displeasure, annoyance, animosity, upset

nag [noun]

means "nuisance"
maenad, pest, annoyance, shrew, termagant, virago

nuisance [noun]

means "pest"
bother, annoyance, irritation, vexation, problem, frump

peevishness [noun]

means "petulance"
testiness, anger, irritability, exasperation, vexation, annoyance

perturbation [noun]

means "irritation"
pique, displeasure, exasperation, ferment, annoyance, distress

pest [noun]

means "nuisance"
annoyance, tease

plague [noun]

means "trouble"
annoyance, disturbance, nuisance, torment, vexation

rub [noun]

means "obstruction"
problem, irritation, annoyance, bother, obstacle, difficulty

ruffle [noun]

means "disturbance"
agitation, annoyance, commotion, confusion, bustle, flurry

- translate ruffle

unrest [noun]

means "agitation"
annoyance, chagrin, disquiet, perturbation, trouble, upset

vexation [noun]

means "irritation"
exasperation, fuss, aggravation, annoyance, torment, uneasiness

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Synonym for annoyance [noun]

annoyance [noun]